Researchers at the Medical College of Georgia at Augusta University are searching for a better way to understand why many men with prostate cancer end up with Alzheimer's disease, and whether it's the standard hormone therapy treatment or an overactive immune response that contributes to the problem.
The hormone therapy, androgen deprivation therapy, known as ADT, treats the cancer by reducing testosterone, which the cancer needs to grow. But androgen is a key regulator of amyloid metabolism and when it's removed from the equation, more amyloid is left to form the plaques that are a hallmark of Alzheimer's.
"We know that prostate cancer itself also largely affects men over age 65, which is a population that's already at a higher risk of Alzheimer's, simply due to their age," said Qin Wang, MD/PhD, Georgia Research Alliance Eminent Scholar in Neurodegeneration and inaugural director of the Program for Alzheimer's Therapeutic Discovery at MCG. "What is not largely understood is the role ADT may play in the context of cancer and Alzheimer's disease."
Know more: https://www.sciencedaily.com/releases/2024/08/2408...

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