Researchers have shown a new compound delivered in a nasal spray is highly effective in preventing and treating COVID-19 caused by the Delta variant in mice.
The researchers, including at UBC, Université de Sherbrooke, and Cornell University, believe this is the first treatment of its kind proven to be effective against all COVID-19 variants of concern reported to date, including alpha, beta, gamma and delta. Published today in Nature, the research opens the door to developing a therapeutic spray for humans.
Variants of concern, including the recent Omicron variants, have reduced vaccine effectiveness, but senior author Dr. François Jean, associate professor in the UBC department of microbiology and immunology, says early, still unpublished results from his team show promise that N-0385 is also effective at blocking Omicron variant infections in human lung cells. "Our unpublished results represent encouraging findings with the current rapid propagation of Omicron BA.2 around the world."