Scientists at Stanford Medicine conducted a study describing a new category of depression -- labeled the cognitive biotype -- which accounts for 27% of depressed patients and is not effectively treated by commonly prescribed antidepressants.
Cognitive tasks showed that these patients have difficulty with the ability to plan, display self-control, sustain focus despite distractions and suppress inappropriate behavior; imaging showed decreased activity in two brain regions responsible for those tasks.
Because depression has traditionally been defined as a mood disorder, doctors commonly prescribe antidepressants that target serotonin (known as selective serotonin reuptake inhibitors or SSRIs), but these are less effective for patients with cognitive dysfunction. Researchers said that targeting these cognitive dysfunctions with less commonly used antidepressants or other treatments may alleviate symptoms and help restore social and occupational abilities.
Know more: https://www.sciencedaily.com/releases/2023/06/2306...

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